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Metabolic Stability in Drug Development: 5 Assays

Metabolic Stability in Drug Development: 5 Assays

Metabolic stability is the susceptibility of compounds to biotransformation, which has a major impact on the efficacy and safety of drugs. Here are five assays that evaluate metabolic stability in the drug development process.

Revolutionizing Plasma Protein Binding Determination with Echo® MS

Revolutionizing Plasma Protein Binding Determination with Echo® MS

Plasma protein binding (PPB) assays are critical in the drug discovery process. However, this stage of development can be complex, time-consuming and expensive. So, any advancement in the technology used to carry out PPB assays is welcome news for drug sponsors and...

3 Common Missteps in Nonclinical Safety Assessment Testing

3 Common Missteps in Nonclinical Safety Assessment Testing

Safety assessment testing is one of the most involved and complex pieces of an already time-intensive and costly drug development process. Any missteps here can have drastic implications on the rest of your development program. Here are three common pitfalls to avoid....

Early ADME Screening: 3 Ways It Boosts IND Submission Success

Early ADME Screening: 3 Ways It Boosts IND Submission Success

Thorough testing of the absorption, distribution, metabolism, and excretion (ADME) properties of a compound has significant downstream effects on the potential success of a drug. Here’s how early ADME screening in particular helps propel you to a successful IND...

Decoding Complex Metabolite Related Drug-Drug Interactions

Decoding Complex Metabolite Related Drug-Drug Interactions

Drug-drug interaction (DDI) signifies an essential facet of pharmacological science, given its influence on drug efficacy and the potential for adverse events. DDI occurs when the pharmacological or clinical response to a drug is altered by the presence of another...

Drug-Drug Interaction: An Overview of Inhibitors

Drug-Drug Interaction: An Overview of Inhibitors

Unexpected side effects can occur when two or more drugs are co-administered. These are called Drug-Drug Interactions (DDIs). Most drugs rely on enzymes to be metabolized. These interactions can alter the efficacy of a drug and potentially be harmful or less...

Tackling Development and Regulatory Challenges for Gene Therapies

Tackling Development and Regulatory Challenges for Gene Therapies

Gene therapies have been one of the fastest-growing fields of drug development. These therapies hold the potential to treat cancers and other “undruggable” diseases and could hold the key to saving millions of lives. But they also have unique characteristics that make...