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QWBA vs. Mass Balance Studies

QWBA vs. Mass Balance Studies

Quantitative whole-body autoradiography (QWBA) and mass balance testing are equally important processes to gather data on a drug candidate’s absorption, distribution, metabolism, and excretion (ADME) properties.  While both QWBA and mass balance can give details...

How to Improve PROTACs’ Oral Bioavailability

How to Improve PROTACs’ Oral Bioavailability

PROteolysis TArgeting Chimera (PROTAC)* drugs hold enormous potential. No PROTAC drugs have earned FDA approval yet, but they are being widely explored across industry and academia for an ever-expanding range of treatments.  Part of PROTACs’ appeal is in their...

A Guide to In Vitro ADME Testing in Drug Development

A Guide to In Vitro ADME Testing in Drug Development

Understanding the Absorption, Distribution, Metabolism and Excretion (ADME) properties of a compound is critical to drug discovery and development. In this short guide, we look at how in vitro ADME testing works and why it is important. To understand in vitro ADME...