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Non-Clinical Mass Balance and Tissue Distribution

An Integrated Solution for a Successful Program

When you work with WuXi AppTec, you can leverage our experience and expertise in mass balance and Quantitative Whole Body Autoradiography (QWBA) as part of a comprehensive set of in vivo ADME services. Utilizing state-of-the-art facilities, our integrated solution includes Excretion Balance, QWBA and Metabolite Profiling and Identification. Our Capabilities Include: 

Bile Duct Cannulated (BDC) and Mass Balance 

  • Exploratory BDC study with cold compounds
  • Mass Balance with radiolabeled test articles in rodents, canines and Non-Human Primates (NHP)
  • Determination of excretion kinetics in urine, feces, expired air and bile
  • Pharmacokinetics of parent and total radioactivity (= total drug mass)
  • Combination studies of mass balance and QWBA


Whole Body Autoradiography (QWBA)


  • Quantitative/qualitative whole body autoradiography:
    • Tissue distribution
    • Placental transfer
    • Large animal organ or tissue autoradiography
  • Cryo-Imaging and Quantitative Autoradiography (CIQA):
    • Optical image verification of radioactivity
    • Standard 2D and enhanced 3D image analysis
  • Turnkey study services:
    • Study design consultation
    • Pharmacokinetic (PK) analysis
    • Dosimetry calculations
  • State-of-the-art laboratory features
  • Leica®/Vibratome microtomes, PerkinElmer® oxidizers and GE Typhoon™ image scanner
  • DEBRA™ Laboratory Information Management System (LIMS)
  • Liquid scintillation counters, TopCount® and beta-counters
  • 14C or 3H isotopes