Large Animal Pharmacokinetics

Compound Advancement

As your partner, we are an extension of your team utilizing a full package of services to support the development of your compounds. We work with you to design studies, analyze the data and provide the insights you need to advance your compounds through development.


  • Capacity of 1,000 large animals including dogs, Non-Human Primates (NHP), pigs and rabbits in Pharmacokinetic (PK) studies
    • A stock colony maintained to minimize the study lead times
    • An integrated animal individual file tracking system
  • 2,000 m² / 22,000 ft² AAALAC (The Association for Assessment and Accreditation of Laboratory Animal Care International) accredited vivarium
  • NHP breeding facility with abundant supply
  • Husbandry according to U.S. and EU standards
  • OLAW (Office of Laboratory Animal Welfare) assurance approved
  • Over 60 well-trained and organized technicians
  • 10+ AALAS (American Association for Laboratory Animal Science) certificates
  • Capacity: >100 arms per week
  • Human-class surgery room, dedicated veterinary surgeons with 10+ years of experience
  • On-site clinical chemistry and pathology


Performance Metrics

  • Minimal lead time for small and large molecule PK in dogs and NHPs
  • Average turnaround time from test article receipt to report delivery:
    • 7 business days for parallel designs
    • 14 days for crossover designs (depending on washout time)


Dosing Routes

  • Intravenous (bolus and infusion)
  • Oral (solution, suspension, capsule and tablet)
  • Intramuscular
  • Subcutaneous
  • Transdermal
  • Intranasal
  • Intra portal vein
  • Intraduodenal
  • Rectal/Vaginal
  • Intraosseous
  • Sublingual, Buccal and gingiva
  • Intracameral
  • Intravitreal
  • Intrathecal injection


Biological Matrices

  • Blood, plasma, serum, bile, urine and feces
  • Cerebrospinal fluid (CSF)
  • Lymph fluid
  • Liver biopsies


Surgical Techniques

  • Jugular vein cannulation
  • Thoracic duct cannulation
  • Bile duct cannulation
  • Duodenum cannulation
  • Portal vein cannulation
  • Cisterna magna cannulation
  • Intestinal cannulation in different segments
  • Lymphatic cannulation
  • Liver biopsy