Large Animal Pharmacokinetics

  • 2,000 m2 / 22,000 ft2 AAALAC accredited vivarium
  • Capacity for 720 dogs and cynomolgus monkeys in PK studies
  • Additionally 100 cynomolgus monkeys for pharmacological models in metabolic disease and CNS
  • Other species include rabbit, guinea pig, Bama minipig
  • Husbandry according to US and EU standards
  • Capacity: >100 arms per week
  • Human-class surgery room, dedicated veterinary surgeons
  • On-site clinical chemistry and pathology

Performance metrics

  • Minimal lead time for small molecule PK in dogs and monkeys
  • For parallel designs, seven-to-nine business days turnaround time, from test article receipt to report delivery
  • For crossover designs, 14 days turnaround time (depending on washout time)
  • >100 bioanalytical scientists
  • The first to apply ADDA and MPXTM-2/Shimadzu Nexera UHPLC-30A LC-MS/MS for high-throughput bioanalysis in China
  • Comprehensive bioanalytical solutions for a wide range of compounds including small molecules, biomarkers and peptides based on the UHPLC-MS/ MS platforms.


 Dosing Route

  • Intravenous (bolus and infusion)
  • Per oral (solution, suspension, or capsule)
  • Intramuscular
  • Subcutaneous
  • Transdermal
  • Intranasal
  • Intra portal vein
  • Intraduodenal
  • Sublingual, Buccal & gingiva
  • Intracameral
  • Intravitreal
  • Intrathecal injection

Biological matrices

    • Blood, plasma, serum, bile, urine, feces
    • CSF
    • Lymph fluid
    • Liver biopsies
    • Other tissues

Surgical techniques

  • Jugular vein cannulation
  • Thoracic duct cannulation
  • Bile duct cannulation
  • Duodenum cannulation
  • Portal vein cannulation
  • Cisterna magna cannulation