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Large Animal Pharmacokinetics

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Advancing Your Compound

As your partner, we act as an extension of your team, leveraging a complete package of services to support the development of your compound. We’ll collaborate with you to design studies, analyze the data and provide the insights you need to advance your compound to the next milestone.

 Our Services Include: 

  • 1,000 large-animal capacity for Pharmacokinetic (PK studies) – including canine, Non-Human Primate (NHP), swine and rabbit
  • Stock colony to minimize study lead times
  • Integrated individual-animal file tracking system
  • 2,000 m² / 22,000 ft² AAALAC (The Association for Assessment and Accreditation of Laboratory Animal Care International)-accredited vivarium
  • NHP breeding facility with abundant supply
  • Husbandry following U.S. and EU standards
  • OLAW (Office of Laboratory Animal Welfare) assurance approved
  • 60+ technicians
  • 10+ AALAS (American Association for Laboratory Animal Science) certificates
  • Capacity: >100 arms per week
  • Human-class surgery room, dedicated veterinary surgeons with 10+ years of experience
  • On-site clinical chemistry and pathology

Performance Metrics

  • Minimal lead time for small- and large-molecule PK in canines and NHPs
  • Average 7 business days turnaround time from test article receipt to report delivery for parallel designs; 14 days for crossover designs (depending on washout time)

Dosing Routes

  • Intravenous (bolus and infusion)
  • Oral (solution, suspension, capsule and tablet)
  • Intramuscular
  • Subcutaneous
  • Transdermal
  • Intranasal
  • Intra portal vein
  • Intraduodenal
  • Rectal/Vaginal
  • Intraosseous
  • Sublingual, Buccal and gingiva
  • Intracameral
  • Intravitreal
  • Intrathecal injection

 

Biological Matrices

  • Blood, plasma, serum, bile, urine and feces
  • Cerebrospinal fluid (CSF)
  • Lymph fluid
  • Liver biopsies

 

Surgical Techniques

  • Jugular vein cannulation
  • Thoracic duct cannulation
  • Bile duct cannulation
  • Duodenum cannulation
  • Portal vein cannulation
  • Cisterna magna cannulation
  • Intestinal cannulation in different segments
  • Lymphatic cannulation
  • Liver biopsy