Digital Learning
Scientific Posters
WRIB, 2024
Novel DNA purification method facilitates the bioanalysis of DNA-based gene therapeutics in whole blood samples
WRIB, 2024
LCMS-Based Strategies For In Vivo Dar Characterization In NHP Serum
WRIB, 2024
A Novel Whole Blood Cryopreservation Method For Flow Cytometry Based Leucocyte Immunophenotyping
SOT, 2024
Comparison of Changes of Hematology & Coagulation in Fasted & Non-fasted Non-Human Primates
SOT, 2024
Case Study: Re-consider Using Flow Cytometry for In Vivo Micronucleus Assay
SOT, 2024
Novel Approach to Mitigate Pharmacological Actions of a Novel Hedgehog (Hh) and Smoothened (Smo) Inhibitor to Successfully Complete a 26 Week Rat Study
SOT, 2024
Spontaneous Ocular Abnormalities in Sprague-Dawley Rats
SOT, 2024
Retrospective Review of Tolerable Levels for Polyethylene Glycol in Non-Clinical Studies as a Vehicle Component
SOT, 2024
Comparison of Systemic Exposure in Pregnant and Non-Pregnant Sprague-Dawley Rats
SOT, 2024
Method Development Optimization for Intravesical Instillation in the Rat
SOT, 2024
Consideration of Tongue Toxicity in Ocular Toxicity Studies
SOT, 2024
Establishment of Preclinical Immunotoxicity Reference Based on a Large-scale Immunophenotyping Data in Cynomolgus Monkey
SOT, 2024
A Retrospective Analysis of Internal In Vitro Chromosomal Aberration Data
ACT, 2023
A Retrospective Analysis of Internal In Vitro Phototoxicity Data
ACT, 2023
Comparison of Routine Parameters of Tg.rasH2 Mice and Non-Tg.rasH2 Mice
AAPS, 2023
Validation Of An In Vitro Cell-based Assay For The Detection Of Neutralizing Antibodies Against Adeno-associated Virus 9 In Cynomolgus Monkey
AAPS, 2023
Comparison of Branched DNA (B-DNA) and Reverse Transcription-Polymerase Chain Reaction (RT-qPCR) Method Validation for the Quantification of mRNA Therapeutics in Plasma
AAPS, 2023
Effect of pH on Metabolite Profiling and Identification of GalNAc Conjugated siRNA in In Vitro Metabolic System
AAPS, 2023
A Comprehensive Bioanalytical Strategy of In Vivo Studies for RNAi Therapeutics in Early Discovery
AAPS, 2023
Metabolite Identification of Nucleoside Analog Prodrugs in Biological Matrix by Derivatization Coupled with Radio-Detector and Mass Spectrometry
AAPS, 2023
Quantitative Analysis of GalNAc-siRNA Conjugates in Tissue Homogenate Using Two-Dimensional Liquid Chromatography Coupled with Tandem Mass Spectrometry
AAPS, 2023
Research Strategy of Chiral PROTACs in Discovery Stage Based on Analysis Platforms of UPCC-MS/MS and UPLC-MS/MS
AAPS, 2023
Smart Compound Library Based on Machine Learning, Sensing Technology, and Programmable Logic Control
AAPS, 2023
Study on the Permeability of Ophthalmic Tissues In Vitro
AAPS, 2023
Evidence-Based Strategies for the Characterization of New Chemical Entity (NCE) In Vitro CYP and Non-CYP Enzyme Reaction Phenotyping at the Development Stage
ISSX, 2023
Development of a Convenient In Vitro Method for Predicting Metabolism and Disposition of Acrylamide Covalent Drugs in Humans
ISSX, 2023
Strategies for Enhancing Oral Exposure of Water-Insoluble Compounds
ISSX, 2023
Radiolabeled Mass Balance Studies in Preclinical Animals
ISSX, 2023
Novel Approach to Determine Plasma Protein Binding for Labile Compounds Using Equilibrium Dialysis
ISSX, 2023
Experimental Validation of the Reliability of Dilution Method for Plasma Protein Binding Assay in Human Plasma Using Commercial Compounds
ISSX, 2023
Establishment of the Relay Method for Low Turnover Compounds in Hepatocyte Stability Assays
ISSX, 2023
Development of a Plasma Stability Assay for Oligonucleotides
ISSX, 2023
Smart Compound Library Based on Machine Learning, Sensing Technology, and Programmable Logic Control
ISSX, 2023
Plasma Protein Binding of Oligonucleotides Using Rapid Agarose Gel Electrophoretic Mobility Shift Assay
EuroTox, 2023
Incidence of Common Arrhythmias in Bama Minipigs of Stand-Alone Safety Pharmacology and General Toxicology Studies
EuroTox, 2023
Comparison of the Dermal Histopathological Structure Between the Bama and Göttingen Minipigs
EuroTox, 2023
In Vivo Phototoxicity Studies in Rats and Guinea Pigs with Systemic Administration
EuroTox, 2023
An Evaluation of Detection Sensitivity and Pharmacokinetic Profile for Conscious Telemetered Cynomolgus Monkeys
AAPS, 2023
Development Of An Ultrasensitive qPCR Method To Identify And Quantify Point Mutation In Circulating Tumor DNA
White Papers
Developing a Convenient In Vitro Method for Predicting Metabolism and Disposition of Acrylamide Covalent Drugs in Humans
Detect and Characterize In Vitro PCCs of Non-Cleavable ADCs Using a New LC-HRMS Method
Unknowns are Unacceptable
Pharmacokinetic Bioanalysis Strategies for Antibody-Drug Conjugates (ADCs)
Based on LC-MS
The BAMA MINIPIG in Toxicology
Comparison Between Magnetic Bead and Membrane Immunoaffinity Purification Methods for the Measurement of Monoclonal Antibody in Rat Serum
Internal Standard (IS) Variation Case Studies: Emerging From Three Common IS Challenges
Metabolite Identification (MetID): A Critical Step in Drug Discovery and Development
ICH M10 Guidance: Harmonization and Modification to Bioanalytical Method Variation
The 2019 FDA Guidance’s Implications for Immunogenicity Assessment
Bridging Preclinical and Clinical Assays for Biologics Development –Challenges and Considerations for Phase I Trials
Webinars
Past Webinars
Challenges and solutions in bioanalysis for oligonucleotide drugs
DPMK Strategies in the Preclinical Development of Antibody-Drug Conjugates
Facilitating ADC Preclinical DMPK Research with An Integrated Bioanalysis Platform
Discovery, Characterization, and Manufacture of Peptide Radiopharmaceuticals
Designing Extractable/Leachable Studies for Drugs and Biologics
Designing Extractable/Leachable Studies for Drugs and Biologics
DMPK Strategies for Oligonucleotide Therapeutics
Hot Topics and Challenges in Drug Development
The Strategies and Methods of in-vitro ADME Characterizations of ADCs
DMPK Strategies for Successful Clinical Translation
DMPK Addressing Safety Testing of Drug Metabolites (MIST) in Drug Development
ICP-MS
Expediting Biologics Drug Development: Strategies to Accelerate Preclinical Development Timelines
DMPK Optimization of Proteolysis-Targeting Chimeras
Preclinical Oligonucleotide Drug Development: Insight from DMPK
Brochures
IND, Enabled
Bioanalytical Services
Oligonucleotide Drugs
Proteolysis Targeting Chimera
Peptide
Antibody Drug Conjugate
Peptide-Drug Conjugate
Safety Assessment Services
Service Catalog
Drug Metabolism and Pharmacokinetics
Presentations
Check out our 15-minute presentation on the revolutionary impact of ADCs in targeted cancer therapy. Detailing their journey from conception to becoming a leading treatment modality, we highlight the significant bioanalytical challenges and regulatory milestones that shape ADC development.
What you will learn:
- The components of ADCs and their roles in targeting and killing tumor cells
- Bioanalytical details on PK, PD, immunogenicity, receptor occupancy and immunotoxicity studies
- Analytical platforms and techniques
- Challenges in ADC bioanalysis
- Guidelines and strategies for biomarker bioanalysis