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Scientific Posters

 

WRIB, 2024

Novel DNA purification method facilitates the bioanalysis of DNA-based gene therapeutics in whole blood samples

WRIB, 2024

LCMS-Based Strategies For In Vivo Dar Characterization In NHP Serum

WRIB, 2024

A Novel Whole Blood Cryopreservation Method For Flow Cytometry Based Leucocyte Immunophenotyping

SOT, 2024

Comparison of Changes of Hematology & Coagulation in Fasted & Non-fasted Non-Human Primates

SOT, 2024

Case Study: Re-consider Using Flow Cytometry for In Vivo Micronucleus Assay

SOT, 2024

Novel Approach to Mitigate Pharmacological Actions of a Novel Hedgehog (Hh) and Smoothened (Smo) Inhibitor to Successfully Complete a 26 Week Rat Study

SOT, 2024

Spontaneous Ocular Abnormalities in Sprague-Dawley Rats

SOT, 2024

Retrospective Review of Tolerable Levels for Polyethylene Glycol in Non-Clinical Studies as a Vehicle Component

SOT, 2024

Comparison of Systemic Exposure in Pregnant and Non-Pregnant Sprague-Dawley Rats

SOT, 2024

Method Development Optimization for Intravesical Instillation in the Rat

SOT, 2024

Consideration of Tongue Toxicity in Ocular Toxicity Studies

SOT, 2024

Establishment of Preclinical Immunotoxicity Reference Based on a Large-scale Immunophenotyping Data in Cynomolgus Monkey

SOT, 2024

A Retrospective Analysis of Internal In Vitro Chromosomal Aberration Data

ACT, 2023

A Retrospective Analysis of Internal In Vitro Phototoxicity Data

ACT, 2023

Comparison of Routine Parameters of Tg.rasH2 Mice and Non-Tg.rasH2 Mice

AAPS, 2023

Validation Of An In Vitro Cell-based Assay For The Detection Of Neutralizing Antibodies Against Adeno-associated Virus 9 In Cynomolgus Monkey

AAPS, 2023

Comparison of Branched DNA (B-DNA) and Reverse Transcription-Polymerase Chain Reaction (RT-qPCR) Method Validation for the Quantification of mRNA Therapeutics in Plasma

AAPS, 2023

Effect of pH on Metabolite Profiling and Identification of GalNAc Conjugated siRNA in In Vitro Metabolic System

AAPS, 2023

A Comprehensive Bioanalytical Strategy of In Vivo Studies for RNAi Therapeutics in Early Discovery

AAPS, 2023

Metabolite Identification of Nucleoside Analog Prodrugs in Biological Matrix by Derivatization Coupled with Radio-Detector and Mass Spectrometry

AAPS, 2023

Quantitative Analysis of GalNAc-siRNA Conjugates in Tissue Homogenate Using Two-Dimensional Liquid Chromatography Coupled with Tandem Mass Spectrometry

AAPS, 2023

Research Strategy of Chiral PROTACs in Discovery Stage Based on Analysis Platforms of UPCC-MS/MS and UPLC-MS/MS

AAPS, 2023

Smart Compound Library Based on Machine Learning, Sensing Technology, and Programmable Logic Control

AAPS, 2023

Study on the Permeability of Ophthalmic Tissues In Vitro

AAPS, 2023

Evidence-Based Strategies for the Characterization of New Chemical Entity (NCE) In Vitro CYP and Non-CYP Enzyme Reaction Phenotyping at the Development Stage

ISSX, 2023

Development of a Convenient In Vitro Method for Predicting Metabolism and Disposition of Acrylamide Covalent Drugs in Humans

ISSX, 2023

Strategies for Enhancing Oral Exposure of Water-Insoluble Compounds

ISSX, 2023

Radiolabeled Mass Balance Studies in Preclinical Animals

ISSX, 2023

Novel Approach to Determine Plasma Protein Binding for Labile Compounds Using Equilibrium Dialysis

ISSX, 2023

Experimental Validation of the Reliability of Dilution Method for Plasma Protein Binding Assay in Human Plasma Using Commercial Compounds

ISSX, 2023

Establishment of the Relay Method for Low Turnover Compounds in Hepatocyte Stability Assays

ISSX, 2023

Development of a Plasma Stability Assay for Oligonucleotides

ISSX, 2023

Smart Compound Library Based on Machine Learning, Sensing Technology, and Programmable Logic Control

ISSX, 2023

Plasma Protein Binding of Oligonucleotides Using Rapid Agarose Gel Electrophoretic Mobility Shift Assay

EuroTox, 2023

Incidence of Common Arrhythmias in Bama Minipigs of Stand-Alone Safety Pharmacology and General Toxicology Studies

EuroTox, 2023

Comparison of the Dermal Histopathological Structure Between the Bama and Göttingen Minipigs

EuroTox, 2023

In Vivo Phototoxicity Studies in Rats and Guinea Pigs with Systemic Administration

EuroTox, 2023

An Evaluation of Detection Sensitivity and Pharmacokinetic Profile for Conscious Telemetered Cynomolgus Monkeys

AAPS, 2023

Development Of An Ultrasensitive qPCR Method To Identify And Quantify Point Mutation In Circulating Tumor DNA

White Papers

Developing a Convenient In Vitro Method for Predicting Metabolism and Disposition of Acrylamide Covalent Drugs in Humans

Detect and Characterize In Vitro PCCs of Non-Cleavable ADCs Using a New LC-HRMS Method

Unknowns are Unacceptable

Pharmacokinetic Bioanalysis Strategies for Antibody-Drug Conjugates (ADCs)
Based on LC-MS

The BAMA MINIPIG in Toxicology

Comparison Between Magnetic Bead and Membrane Immunoaffinity Purification Methods for the Measurement of Monoclonal Antibody in Rat Serum

Internal Standard (IS) Variation Case Studies: Emerging From Three Common IS Challenges

Metabolite Identification (MetID): A Critical Step in Drug Discovery and Development

ICH M10 Guidance: Harmonization and Modification to Bioanalytical Method Variation

The 2019 FDA Guidance’s Implications for Immunogenicity Assessment

Bridging Preclinical and Clinical Assays for Biologics Development –Challenges and Considerations for Phase I Trials

Webinars

Upcoming Webinars

The development of oligonucleotide-based therapeutics has recently attracted extensive attention due to their eminent potential. Oligonucleotide therapies have many advantages, including ease of design, a wide range of targets, and high specificity. However, the chemical characteristics of oligonucleotides pose a significant challenge for bioanalysis. In addition, oligonucleotides’ immunogenicity and immunotoxicity potential are of concern in pre-clinical and clinical trials. To better facilitate oligonucleotide drug development, we share some bioanalytical strategies and case studies regarding the mitigation of these challenges.

Past Webinars

DPMK Strategies in the Preclinical Development of Antibody-Drug Conjugates

Facilitating ADC Preclinical DMPK Research with An Integrated Bioanalysis Platform

Designing Extractable/Leachable Studies for Drugs and Biologics

Discovery, Characterization, and Manufacture of Peptide Radiopharmaceuticals

Designing Extractable/Leachable Studies for Drugs and Biologics

Preclinical Oligonucleotide Drug Development: Insight from DMPK

DMPK Strategies for Oligonucleotide Therapeutics

Hot Topics and Challenges in Drug Development

The Strategies and Methods of in-vitro ADME Characterizations of ADCs

DMPK Strategies for Successful Clinical Translation

DMPK Addressing Safety Testing of Drug Metabolites (MIST) in Drug Development

DMPK Challenges and Strategies for Developing Oligonucleotide Drugs

ICP-MS

Expediting Biologics Drug Development: Strategies to Accelerate Preclinical Development Timelines

DMPK Optimization of Proteolysis-Targeting Chimeras

Brochures

Safety Assessment Services Brochure

IND, Enabled

Safety Assessment Services Brochure

Bioanalytical Services

Safety Assessment Services Brochure

Oligonucleotide Drugs

Safety Assessment Services Brochure

Proteolysis Targeting Chimera

Safety Assessment Services Brochure

Peptide

Safety Assessment Services Brochure

Antibody Drug Conjugate

Safety Assessment Services Brochure

Peptide-Drug Conjugate

Safety Assessment Services Brochure

Safety Assessment Services

Service Catalog

Drug Metabolism and Pharmacokinetics