Rodent Pharmacokinetics

  • 4000 m2 / 43000 ft2 AAALAC accredited vivarium
  • Both conventional and barriers
  • 42 dedicated study rooms, three surgery/recovery rooms
  • Separated cage washing, food storage and freezer room
  • Over 85 well-trained and organized technicians
  • Experienced in formulation screening and safety evaluation of test items
  • >30 surgery techniques for mice and rats
  • Full capacity: dose over 600 arms per week

Species

  • Mouse: Wild types: CD-1, C57BL/6, BALB/c, FVB Transgenic: Pgp-KO, BCRP-KO
  • Rat: HW, SD, Lewis, etc.
  • Hamster, gerbil

Performance metrics

  • Average five-to-seven business days turnaround time from test article receipt to report delivery
  • 95% of all studies complete within 10 business days
  • <1% repeat rate

Capabilities

 Dosing Route

  • Intravenous (bolus and infusion)
  • Per oral (solution, suspension, or capsule)
  • Intramuscular
  • Subcutaneous
  • Transdermal
  • Intranasal
  • Inhalation
  • Endotracheal injection
  • Ocular instillation
  • Ocular intravitreal injection
  • Intraduodenal
  • Rectal
  • Stereotactic application (e.g. ICV)s
  • Mini-pump
  • Intra portal vein

Biological matrices

  • Blood, plasma, serum, bile, urine, feces
  • CSF
  • Lymph fluid
  • Bone marrow, diverse healthy tissues and tumors

Surgical techniques

  • Jugular vein cannulation
  • Carotid artery cannulation
  • Mesenteric lymph duct cannulation
  • Bile duct cannulation
  • Femoral vein cannulation
  • Femoral artery cannulation
  • Duodenum cannulation
  • Portal vein cannulation
  • Microdialysis