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Rodent Pharmacokinetics

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Expert Support to Advance Your Compound

WuXi AppTec’s highly trained DMPK team can support your rodent Pharmacokinetics (PK) needs from discovery to New Drug Application (NDA). With expertise in study design, execution, and data analysis, we can help you make the right decisions to help you understand and advance your compound. 

Our Capabilities Include:

  • 4000 m² / 43000 ft² AAALAC (The Association for Assessment and Accreditation of Laboratory Animal Care International)-accredited barrier vivarium
  • EU standard for animal husbandry
  • OLAW (Office of Laboratory Animal Welfare) assurance approved
  • 110+ technicians
  • 60+ rodent surgery techniques
  • 20+ international-standard AALAS (American Association for Laboratory Animal Science) certificates
  • 20+ dosing routes
  • 15+ surgery models
  • 800+-arm per week dosing capacity
  • Formulation screening and physicochemical analysis

 

Species 

Mouse: Wild types: CD-1, C57BL/6, BALB/c, FVB, nude mouse & SCID mouse

Transgenic: Pgp-KO and BCRP-KO

Rat: Wistar Han, SD, Lewis, etc.

Hamster

Gerbil

Guinea pig

 

Performance metrics

  • Average five business days turnaround from test article receipt to report delivery
  • 95% of all studies completed within 10 business days
  • <0.3% repeat rate

 

Dosing Routes

  • Intravenous (bolus and infusion)
  • Oral (solution, suspension or capsule)
  • Intramuscular
  • Subcutaneous
  • Intraperitoneal
  • Transdermal
  • Intradermal
  • Sublingual
  • Intranasal
  • Intratracheal (instillation & Penny spray)
  • Inhalation (aerosol & powder)
  • Endotracheal injection
  • Ocular instillation
  • Ocular intravitreal injection
  • Intraduodenal
  • Rectal
  • Stereotactic application (e.g. ICV)s
  • Mini-pump (IP, SC and IV)
  • Intra portal vein
  • Intraarticular
  • Intratympanic
  • Intravaginal
  • Intravesical

 

Biological Matrices 

  • Blood, plasma, serum, bile urine and feces
  • Cerebrospinal fluid (CSF)
  • Lymph fluid
  • Bone marrow, diverse healthy tissues and tumors
  • Peripheral Blood Mononuclear Cells (PBMC)

 

Surgical Techniques

 

Survival Surgery

  • Jugular vein cannulation – rat and mouse
  • Carotid artery cannulation – rat
  • Mesenteric lymph duct cannulation – rat
  • Bile duct cannulation – rat and mouse
  • Femoral vein cannulation – rat
  • Femoral artery cannulation – rat
  • Duodenum cannulation – rat
  • Portal vein cannulation – rat
  • Microdialysis – brain, vessel and skin 

Non-survival Surgery

  • In situ Single-Pass Intestinal Perfusion (SPIP) – rat and mouse
  • In situ brain perfusion – rat and mouse
  • Ex vivo liver perfusion (single and recirculation) – rat and mouse
  • Blood-brain Barrier Disruption (BBBD) – rat and mouse