Rodent Pharmacokinetics

A Highly Trained Team

The WuXi AppTec DMPK team can support your rodent Pharmacokinetics (PK) needs from Discovery to New Drug Application (NDA). Providing a highly trained team with expertise in study design, execution of studies and analysis of data, we help you make the decisions that you need to understand and advance your compound.

Overview

  • 4000 m² / 43000 ft² AAALAC (The Association for Assessment and Accreditation of Laboratory Animal Care International) accredited barrier vivarium
  • EU standard for animal husbandry
  • OLAW (Office of Laboratory Animal Welfare) assurance approved
  • 110+ well-trained and organized technicians
  • 60+ surgery techniques for rodents
  • 20+ AALAS (American Association for Laboratory Animal Science) certificates – international standard
  • 20+ dosing routes
  • 15+ surgery models
  • Full capacity: dose over 800 arms per week
  • Formulation screening and physicochemical analysis

Species

  • Mouse:
    • Wild types: CD-1, C57BL/6, BALB/c, FVB, nude mouse and SCID mouse
    • Transgenic: Pgp-KO and BCRP-KO
  • Rat: Wistar Han, SD and Lewis, etc
  • Hamster
  • Gerbil
  • Guinea pig

Performance metrics

  • Average a five business day turnaround time from test article receipt to report delivery
  • 95% of all studies completed within 10 business days
  • <0.3% repeat rate

Dosing Routes

  • Intravenous (bolus and infusion)
  • Oral (solution, suspension, or capsule)
  • Intramuscular
  • Subcutaneous
  • Intraperitoneal
  • Transdermal
  • Intradermal
  • Sublingual
  • Intranasal
  • Intratracheal (instillation and Penny spray)
  • Inhalation (aerosol and powder)
  • Endotracheal injection
  • Ocular instillation
  • Ocular intravitreal injection
  • Intraduodenal
  • Rectal
  • Stereotactic application (e.g. ICV)s
  • Mini-pump (IP, SC and IV)
  • Intra portal vein
  • Intraarticular
  • Intratympanic
  • Intravaginal
  • Intravesical

Biological matrices

  • Blood, plasma, serum, bile, urine and feces
  • Cerebrospinal fluid (CSF)
  • Lymph fluid
  • Bone marrow, diverse healthy tissues and tumors
  • Peripheral Blood Mononuclear Cells (PBMC)

 

Surgical Techniques

Survival Surgery

  • Jugular vein cannulation – rat and mouse
  • Carotid artery cannulation – rat
  • Mesenteric lymph duct cannulation – rat
  • Bile duct cannulation – rat and mouse
  • Femoral vein cannulation – rat
  • Femoral artery cannulation – rat
  • Duodenum cannulation – rat
  • Portal vein cannulation – rat
  • Microdialysis – brain, vessel and skin

 

Non-survival Surgery

  • In situ Single-Pass Intestinal Perfusion (SPIP) – rat and mouse
  • In situ brain perfusion – rat and mouse
  • Ex vivo liver perfusion (single and recirculation) – rat and mouse
  • Blood-brain Barrier Disruption (BBBD) – rat and mouse