Genetic Toxicology

Genetic & in vitro Toxicology

The genetic toxicology division performs both non-GLP and GLP genotoxicity assessments for regulatory filings as well as screening assays for safety lead optimization. Utilizing industry-leading instruments, technologies and expertise, our genetic toxicologists and study directors are committed to presenting rapid, high-quality data that can inform of potential damage during subsequent stages of development.

Genetic Toxicity Screening Assays

  • Mini Ames assay
  • Microwell micronucleus assay

Genetic Toxicity GLP Assays

  • Ames assay
  • in vitro chromosomal aberration assay
  • in vitro micronucleus assay
  • Mouse lymphoma assay
  • in vivo micronucleus assay in rodents

GLP or non-GLP in vitro Cytotoxicity Assays for Biocompatibility

  • MTT assay
  • MEM elution assay
  • Agarose overlay assay
  • Neutral red uptake assay
  • Relative growth rate method
  • Direct contact method

GLP or non-GLP in vitro Phototoxicity Assay

  • 3T3 NRU phototoxicity assay
  • GLP in vitro electrophysiology assay
  • hERG assay