Molecular Imaging Services
WuXi AppTec offers cutting-edge molecular imaging services to enhance your preclinical research. Our advanced imaging technologies provide unparalleled insights into drug behavior, efficacy, and safety, ensuring that your development program stays on the path to success.
Advanced Molecular Imaging for
Drug Development
Our comprehensive imaging services address targeted research needs across drug development—including preclinical animal models, pharmacokinetics, and bioanalysis, and a variety of radiolabeling applications.
Advanced Technology
Our imaging center is equipped with the latest technology, including PET and CT, providing high-resolution, real-time images.
Expert Team
Our team of experienced scientists and imaging specialists work closely with you to design and execute studies tailored to your specific needs.
Customizable Protocols
Our services are flexible and customizable to align with your research goals and regulatory requirements.
Regulatory Application
Full AAALAC accreditation animal facility; in accordance with GMP standards for radiolabeling; and in accordance with GLP standards for Radiopharmaceutical Investigation.
Comprehensive Solutions
We offer integrated imaging services to provide a complete picture of your drug’s behavior and efficacy.
Animal Model Imaging
Our state-of-the-art imaging center supports a wide range of animal models, allowing for detailed visualization of drug interactions and effects in vivo. From small rodents to larger models, we provide high-resolution images to facilitate comprehensive analysis and accurate data interpretation.
Pharmacokinetics
Pharmacokinetics (PK): distribution, and excretion of your drug in real time. Our imaging technologies and intro gamma counter measurement provide precise data on how your drug disperses and persists within the body. Biodistribution: Visualize the distribution of your drug across various tissues and organs. Understanding where your drug accumulates helps in optimizing dosage and targeting.
Bioanalysis
Integrate imaging data with bioanalytical techniques to gain a deeper understanding of drug interactions at the molecular level. Our bioanalysis services complement imaging results and in vitro tissue gamma counter measurement, offering a holistic view of drug efficacy and safety.
Preclinical Research
Our imaging services enable the non-invasive tracking of disease progression, drug distribution, and treatment efficacy to optimize study designs and accelerate development.
Radio Labeling
Our radio labeling services enhance the precision and effectiveness of molecular imaging studies by incorporating radioactive tracers into your compounds.
Peptide Labeling
Label peptides with radioactive isotopes to track their distribution and interaction within biological systems. This is essential for studying peptide behavior and efficacy.
Antibody Labeling
Attach radioactive labels to antibodies for detailed imaging of antibody-target interactions. This is critical for evaluating therapeutic antibodies and understanding their biodistribution.
Protein Labeling
Incorporate radioactive labels into proteins to monitor their localization and interaction in vivo. This technique is vital for studying protein behavior and optimizing drug candidates.
Nano-particle Labeling
Label nanoparticles with radioactive tracers to study their distribution, cellular uptake, and therapeutic efficacy. This is particularly useful for advanced drug delivery systems and targeted therapies.
Radiopharmaceutical Services
& Investigation
WuXi AppTec specializes in advanced radiopharmaceutical solutions to support your drug development and preclinical research needs.
Our comprehensive services cover all aspects of radiopharmaceutical investigation, from labeling and biodistribution to dosimetry and preclinical research.
Labeling Method
Our expertise in radiolabeling ensures precise incorporation of radioactive isotopes into your compounds. This process is critical for tracking and analyzing the behavior of your radiopharmaceuticals in biological systems.
Pharmacodynamics
Evaluate the physiological effects and therapeutic efficacy of your radiopharmaceutical. Our services help you assess the drug’s impact on biological processes and its potential therapeutic benefits.
Biodistribution
Assess the distribution of your radiopharmaceutical throughout the body. Our advanced imaging techniques and in vitro assays provide detailed insights into how your compound spreads across various tissues and organs, helping you optimize dosing and targeting strategies.
Dosimetry
Calculate the radiation dose delivered to tissues and organs. Accurate dosimetry is essential for ensuring safety and efficacy in both preclinical and clinical studies.
Pharmacokinetics
Monitor the absorption, distribution, metabolism, and excretion of your radiopharmaceutical. This data is crucial for understanding how your compound behaves over time.
IND Package Preparation
Prepare comprehensive IND (Investigational New Drug) packages with detailed radiopharmaceutical data. Our expertise helps ensure that your submissions meet regulatory requirements and support the advancement of your drug candidate to clinical trials.
Radioactive Isotopes
We offer a range of radioactive isotopes to suit your specific research needs.
Our available isotopes include:
- 18F
- 11C
- 68Ga
- 64Cu
- 89Zr
- 123I
- 13N
- 131I
- 177Lu
- 90Y
- 124I
- 32P
- 99mTc
- 227Th
- 225Ac
- 223Ra
- 203Pb
- 212Pb
- 211At
- 213Bi
Frequently Asked Questions
What is molecular imaging, and why is it important in preclinical studies?
Molecular imaging is a technique used to visualize and measure biological processes in living organisms at the molecular and cellular levels. It is essential in preclinical studies for tracking disease progression, evaluating drug efficacy, and studying biological pathways in real-time.
How does molecular imaging contribute to drug development?
Molecular imaging allows for non-invasive visualization of drug distribution, target engagement, and therapeutic efficacy, enabling earlier and more accurate assessments of drug candidates in preclinical studies.
What types of molecular imaging techniques are available?
Our molecular imaging techniques include positron emission tomography (PET), computed tomography (CT), and optical imaging.
How do you ensure the accuracy and reliability of molecular imaging data?
We use state-of-the-art imaging equipment, standardized protocols, and experienced technicians to ensure accurate, reproducible, and high-quality molecular imaging data for preclinical studies.
What types of preclinical models are used in molecular imaging studies?
Molecular imaging can be applied to various preclinical models, including rodent models, genetically modified animals, and tumor xenografts, allowing for the study of a wide range of diseases and conditions.
What regulatory guidelines must molecular imaging studies adhere to?
Molecular imaging studies must comply with Good Laboratory Practice (GLP) standards and other regulatory guidelines to ensure the quality and integrity of data used for regulatory submissions and drug development.