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EBF, 2024

Development of an Optimized Statistical Method And Full Validation of the Electrochemiluminescence Immunoassay For Detecting Anti-Aav Antibodies In Human Serum

EBF, 2024

Validation Of An In Vitro Cell-Based Assay For The Detection of Neutralizing Antibodies Against Adeno-Associated Virus 9 in Cynomolgus Monkey

Eurotox, 2024

Validating Multi-Ion Channel Inhibition Assays Following Best Practice Considerations

ACT, 2024

Retrospective Study of Survivability and Histopathology Findings in Cannulated Rodents

ACT, 2024

Validation of the Flow-cytometric Peripheral Blood Micronucleus Assay in Mouse

AAPS, 2024

The Application Of 19f-NMR In The Analysis Of Drug-Related Substances Of Leritrelvir (Ray1216) In Human Urine And Fecal Samples To Support A Phase I Clinical Study

SOT, 2024

Method Development Optimization for Intravesical Instillation in the Rat

SOT, 2024

Consideration of Tongue Toxicity in Ocular Toxicity Studies

SOT, 2024

Establishment of Preclinical Immunotoxicity Reference Based on a Large-scale Immunophenotyping Data in Cynomolgus Monkey

AAPS, 2023

Development Of An Ultrasensitive qPCR Method To Identify And Quantify Point Mutation In Circulating Tumor DNA

ACT, 2023

A Retrospective Analysis of Internal In Vitro Phototoxicity Data

ACT, 2023

Comparison of Routine Parameters of Tg.rasH2 Mice and Non-Tg.rasH2 Mice

ISSX, 2023

Plasma Protein Binding of Oligonucleotides Using Rapid Agarose Gel Electrophoretic Mobility Shift Assay

EuroTox, 2023

Incidence of Common Arrhythmias in Bama Minipigs of Stand-Alone Safety Pharmacology and General Toxicology Studies

EuroTox, 2023

Comparison of the Dermal Histopathological Structure Between the Bama and Göttingen Minipigs

ISSX, 2023

Establishment of the Relay Method for Low Turnover Compounds in Hepatocyte Stability Assays

ISSX, 2023

Development of a Plasma Stability Assay for Oligonucleotides

ISSX, 2023

Smart Compound Library Based on Machine Learning, Sensing Technology, and Programmable Logic Control

ISSX, 2023

Radiolabeled Mass Balance Studies in Preclinical Animals

ISSX, 2023

Novel Approach to Determine Plasma Protein Binding for Labile Compounds Using Equilibrium Dialysis

ISSX, 2023

Experimental Validation of the Reliability of Dilution Method for Plasma Protein Binding Assay in Human Plasma Using Commercial Compounds

AAPS, 2023

Evidence-Based Strategies for the Characterization of New Chemical Entity (NCE) In Vitro CYP and Non-CYP Enzyme Reaction Phenotyping at the Development Stage

ISSX, 2023

Development of a Convenient In Vitro Method for Predicting Metabolism and Disposition of Acrylamide Covalent Drugs in Humans

ISSX, 2023

Strategies for Enhancing Oral Exposure of Water-Insoluble Compounds

AAPS, 2023

Research Strategy of Chiral PROTACs in Discovery Stage Based on Analysis Platforms of UPCC-MS/MS and UPLC-MS/MS

AAPS, 2023

Smart Compound Library Based on Machine Learning, Sensing Technology, and Programmable Logic Control

AAPS, 2023

Study on the Permeability of Ophthalmic Tissues In Vitro

AAPS, 2023

A Comprehensive Bioanalytical Strategy of In Vivo Studies for RNAi Therapeutics in Early Discovery

AAPS, 2023

Metabolite Identification of Nucleoside Analog Prodrugs in Biological Matrix by Derivatization Coupled with Radio-Detector and Mass Spectrometry

AAPS, 2023

Quantitative Analysis of GalNAc-siRNA Conjugates in Tissue Homogenate Using Two-Dimensional Liquid Chromatography Coupled with Tandem Mass Spectrometry

AAPS, 2023

Validation Of An In Vitro Cell-based Assay For The Detection Of Neutralizing Antibodies Against Adeno-associated Virus 9 In Cynomolgus Monkey

AAPS, 2023

Comparison of Branched DNA (B-DNA) and Reverse Transcription-Polymerase Chain Reaction (RT-qPCR) Method Validation for the Quantification of mRNA Therapeutics in Plasma

AAPS, 2023

Effect of pH on Metabolite Profiling and Identification of GalNAc Conjugated siRNA in In Vitro Metabolic System

EuroTox, 2023

In Vivo Phototoxicity Studies in Rats and Guinea Pigs with Systemic Administration

EuroTox, 2023

An Evaluation of Detection Sensitivity and Pharmacokinetic Profile for Conscious Telemetered Cynomolgus Monkeys

WRIB, 2022

Development of a Multiplex RT-qPCR Method to Quantify mRNA Transcript

AAPS, 2024

Lumbar Intrathecal Infusion of an siRNA Formulation via Cannulation in Rats

AAPS, 2024

Method Development And Validation Of A Cell-Based Assay For The Detection Of Anti-AAV Neutralizing Antibodies In Human Serum

AAPS, 2024

Overexpression of Human ApoC3 Leads to Hypertriglyceridemia and
Induces Key CVD-related Lipid Biomarkers

AAPS, 2024

Comparative Metabolite Profiling and Identification of a GalNAc-Conjugated siRNA_siRNA01

AAPS, 2024

Comparison Of The Performance Of Luminex-Based And MSD-Based Immunogenicity Assays For Multivalent HPV Vaccines

AAPS, 2024

Development of a Rapid, High Throughput Quantitative Bioanalysis Method for Conjugated Payloads of Protease-Cleavable Antibody-Drug Conjugate (ADC) in Rat Serum Using Automated Immuno-Capture Based UPLC-MS/MS

AAPS, 2024

Simultaneous Quantification Of Multiple ADC Component Concentrations And DAR Profiling With One Aliquot Of Plasma In NHP Toxicology Study By Hybrid LC-Ms

ISSX, 2024

A Rapid Liquid Chromatography-Tandem Mass Spectrometry Method for Quantifying the Metabolites of Seven Major Probe Substrates in Human Liver Microsomes

ISSX, 2024

A Sensitive and Efficient LC-MSMS Method for Creatinine-d5 Analysis in In Vitro OCT2 Inhibition Assay

ISSX, 2024

Assessment of In Vitro Methods for UGT1A1 Inhibition in Recombinant Isozyme

ISSX, 2024

Comparative Metabolite Profiling and Identification of a GalNAc-Conjugated siRNA siRNA01 in Plasma Prepared with Various Anticoagulants Serum and In Vivo Plasma

ISSX, 2024

Development of an In Vitro Platform for Screening UGT Inhibitors Using Human Liver Microsomes

ISSX, 2024

Does the Flux Competition Method Add Significant Value in Species Difference Protein Binding Evaluation

ISSX, 2024

Effects of Anesthesia and Different Lymphatic Fluid Collection Methods on the Lymphatic Transport of Orally Administered Drugs A Comparative Study in Rats

ISSX, 2024

Effects of Lipoprotein Binding and Plasma Dilution on the Accuracy of Ultracentrifugation Method in Plasma Protein Binding

ISSX, 2024

Evaluation of Cytochrome P450 Inhibition in the 7-in-1 Cocktail Using Preferred Substrates Recommended by Regulatory Agencies

ISSX, 2024

Evaluation of Different Tissue Processing Methods in Bama Pig Skin as an Animal Model for Topical Delivery Systems

ISSX, 2024

In Vitro Metabolic Stability Evaluation of ADCs in Plasma and Whole Blood

ISSX, 2024

Is the Dilution Method for Measuring IC50 Shift Values a More Sensitive Approach for Evaluating Time Dependent Inhibition

ISSX, 2024

Rapid Adenosine Bioanalysis with LS-LC-MS

ISSX, 2024

Rapid Determination of Lipophilicity Exploration and Establishment of Reversed-Phase Liquid Chromatography (RPLC) Methods

ISSX, 2024

A Comprehensive Platform for Evaluating the In Vitro CYP Reaction Phenotyping of New Molecular Entities (NME)

Eurotox, 2024

Method Development Optimization for Intravesical Instillation in the Rat

SOT, 2024

A Retrospective Analysis of Internal In Vitro Chromosomal Aberration Data

WRIB, 2024

LCMS-Based Strategies For In Vivo Dar Characterization In NHP Serum

WRIB, 2024

A Novel Whole Blood Cryopreservation Method For Flow Cytometry Based Leucocyte Immunophenotyping

WRIB, 2024

Novel DNA purification method facilitates the bioanalysis of DNA-based gene therapeutics in whole blood samples

SOT, 2024

Comparison of Changes of Hematology & Coagulation in Fasted & Non-fasted Non-Human Primates

SOT, 2024

Case Study: Re-consider Using Flow Cytometry for In Vivo Micronucleus Assay

SOT, 2024

Novel Approach to Mitigate Pharmacological Actions of a Novel Hedgehog (Hh) and Smoothened (Smo) Inhibitor to Successfully Complete a 26 Week Rat Study

SOT, 2024

Spontaneous Ocular Abnormalities in Sprague-Dawley Rats

SOT, 2024

Retrospective Review of Tolerable Levels for Polyethylene Glycol in Non-Clinical Studies as a Vehicle Component

SOT, 2024

Comparison of Systemic Exposure in Pregnant and Non-Pregnant Sprague-Dawley Rats

SOT, 2024

Method Development Optimization for Intravesical Instillation in the Rat

SOT, 2024

Consideration of Tongue Toxicity in Ocular Toxicity Studies

SOT, 2024

Establishment of Preclinical Immunotoxicity Reference Based on a Large-scale Immunophenotyping Data in Cynomolgus Monkey

WRIB, 2021

Development of a Sensitive and Robust qPCR Method to Quantify siRNA Against HBV in Human Plasma

WRIB, 2021

Method Validation for the Evaluation of Plasma Protein Binding of LGX818 and MEK162 by Rapid Equilibrium Dialysis and LC-MS/MS

AAPS, 2021

Determination of Modified Thymidine Phosphorylase Concentration and its Activity in Mouse Serum by LC-MS/MS