Non-Clinical Mass Balance and Tissue Distribution

An Integrated Solution for a Successful Program

When you work with WuXi AppTec, you can leverage our experience and expertise in mass balance and Quantitative Whole Body Autoradiography (QWBA) as part of a comprehensive set of in vivo ADME services. Utilizing state-of-the-art facilities, our integrated solution includes Excretion Balance, QWBA and Metabolite Profiling and Identification. Our Capabilities Include: 

Bile Duct Cannulated (BDC) and Mass Balance 

• Exploratory BDC study with cold compounds
• Mass Balance with radiolabeled test articles in rodents, canines and Non-Human Primates (NHP)
• Determination of excretion kinetics in urine, feces, expired air and bile
• Pharmacokinetics of parent and total radioactivity (= total drug mass)
• Combination studies of mass balance and QWBA

Whole Body Autoradiography (QWBA)

• Quantitative/qualitative whole body autoradiography:
  • Tissue distribution
  • Placental transfer
  • Large animal organ or tissue autoradiography
• Cryo-Imaging and Quantitative Autoradiography (CIQA):
  • Optical image verification of radioactivity
  • Standard 2D and enhanced 3D image analysis
• Turnkey study services:
  • Study design consultation
  • Pharmacokinetic (PK) analysis
  • Dosimetry calculations
• State-of-the-art laboratory features
• Leica®/Vibratome microtomes, PerkinElmer® oxidizers and GE Typhoon™ image scanner
• DEBRA™ Laboratory Information Management System (LIMS)
• Liquid scintillation counters, TopCount® and beta-counters
• 14C or 3H isotopes