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Pathology

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Global Pathology Services

WuXi AppTec’s team of ACVP (American College of Veterinary Pathologists) and CCVP (Chinese College of Veterinary Pathologists) provide expertise in multiple areas, for all types of drugs – including small molecule, large molecule (peptides/proteins/antibodies) and gene and cell therapy.

We evaluate thousands of slides across a variety of animal species every year, and can provide a solution tailored to your specific drug discovery and development needs.

Our full scope of services includes:

Toxicologic Pathology

  • General Toxicologic Pathology: Acute, Subchronic and Chronic Toxicity
  • Carcinogenicity
  • Irritation Pathology (Dermal, Ocular, Vascular)
  • Developmental & Reproductive Pathology
  • Genetic Toxicology Studies
  • Ocular Pathology

Immunopathology

Our team of study directors and pathologists are highly experienced in conducting Tissue Cross-Reactivity (TCR) studies to support research efforts and regulatory submissions for a broad range of antibodies – including monoclonal, bispecific, Antibody-Drug Conjugate (ADC) and nano-antibodies:

  • Full Tissue Bank of Non-Human Primate (NHP) and Other Species
    • Frozen Tissues for TCR Studies
  • Study-Specific Protocols Prepared based on Client Requirements
  • Comprehensive, High-Quality Audited Reports
  • Rapid Scheduling and Reporting
  • U.S. FDA & EMEA Panel Normal Human Tissue Bank (provided by U.S. vendor)

 

We also provide standardized staining with commercially available antibodies and research antibodies. Here are some examples of our validated Immunohistochemistry (IHC) assays/markers:

  • Immune Cells (CD3, CD4, CD8, CD19, CD20, CD38, CD138, CD68, CD159a, MPO, MBP)
  • Cell Proliferation (Ki67)
  • Glial Cells (Iba-1, GFAP)
  • Pancreases (Glucagon, Insulin, Polypeptide, Somatostatin)
  • Customized Marker Development
  • Epidermal Growth Factor Receptor (EGFR)

 

Clinical Pathology

We offer a complete range of clinical pathology services in a variety of animal species:

  • Routine and Non-Routine Serum Hematology, Chemistry, Coagulation and Urinalysis
  • Non-Routine Cerebrospinal Fluid (CSF) Chemistry
  • Urine Microscopic Examination
  • Urine Chemistry Evaluation
  • Bone Marrow Smear Differentials and M:E Ratio

 

Necropsy & Histology

Our full-service necropsy and histology laboratories are staffed by experienced technologists who provide trimming, embedding, sectioning and special staining to support the evolving needs of our clients’ programs.

Necropsy:

  • Variety of Animal Species
  • Tissue Collection and Fixation
    • Full Tissue Collection, 10% NBF and Modified Davidson
  • Special Collection
    • Snap Freezing, Collections for Ribonucleic Acid (RNA), IHC, Electron Microscopy (EM), CSF and Perfusions (whole body/cranial)

Histology

  • Average Baseline Slide Production
    • Over 70,000 Slides Monthly
  • Special Stains
    • Periodic Acid-Schiff (PAS), Cresyl Echt Violet, Masson’s Trichrome, Gomori Trichrome, Mallory Phosphotungstic Acid Haematoxylin (PTAH), Prussian Blue, Von Kossa Calcium, Alcian Blue-PAS-Hematoxylin, Periodic Acid-Methenamine Silver, Alcian Blue, Van Gieson Picric Acid-Acid Fuchsin, Sirius Red, Oil Red O, Modified Safranin O-fast Green and Acid-Fast Stain (AFB)