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Safety Pharmacology

From our world-class safety evaluation center in Suzhou, scientists conduct a full scope of in vitro and in vivo safety pharmacology studies to assess the potential for toxicity across major therapeutic areas, including cardiovascular, gastrointestinal, renal and the central nervous system. As part of our mission to seamlessly deliver high-quality data that enables high-quality drug candidates, we invest in the most advanced technology for data acquisition and processing. We utilize the state-of-the-art Ponemah software platform for data collection and assimilation.

Non-GLP Cardiovascular Safety Screening Assays
+ Guinea pig QT assay
+ Rat telemetry studies
+ SHR studies for cardiovascular efficacy
+ EKG and indirect blood pressure in dogs and NHPs
+ hERG assay

GLP Safety Pharmacology Studies
+ Functional Observational Battery (FOB) studies in rats and mice
+ CNS system evaluation in mice, rats, dogs and NHPs
+ Cardiovascular telemetry studies in conscious dogs, NHPs and minipigs
+ Jacketed External Telemetry (JET) in conscious dogs and NHPs
+ Respiratory system studies in conscious rats and mice (head-out plethysmographs), dogs and NHPs
+ hERG assay
+ Gastrointestinal motility studies in rats and mice
+ Renal function in rats