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Ocular Toxicology / Toxicokinetics

WuXi’s dedicated ophthalmology lab advances drug development for a wide range of ophthalmic indications using the most advanced ocular PD, PK and toxicology evaluation techniques. Ocular toxicology studies are available as single- or repeat-dose and can be conducted across a variety of species and in various dosage routes, including systemic, topical, subconjunctival, intravitreal, sub-retinal and retrobalbar.

Comparative Ophthalmology

Using slit-lamp and indirect ophthalmoscopy to examine the anterior and posterior segments of the eye, scientists in the comparative ophthalmology research division study the ophthalmological toxicity of animal diseases that can be used as human disease models. Available species include humans, non-human primates, dogs, rabbits and rodents.

Ocular Pharmacokinetics (PK)

Ocular PK studies assess tissue distribution and pharmacokinetics caused by ocular or systemic administration and can be conducted across a variety of species, tissues and liquids using state-of-the-art evaluation techniques.

Eye Tissue Dissection
+ Conjunctivae
+ Cornea
+ Iris / ciliary body
+ Lens
+ Retina / choroid
+ Sclera
+ Optic nerve

Liquid Sampling
+ Aqueous humor
+ Vitreous humor
+ Serum

Evaluation Method
+ Enzyme-linked immunosorbent assay
+ Immunohistochemistry

Ocular Pharmacodynamics (PD)

Ocular PD studies assess the efficacy of new ocular drugs in developed animal ocular disease models. The following available models can be developed in collaboration with the client:

+ Dry eye induced by benzalkonium instillation
+ Acute glaucoma induced by intracameral injection of VISCOAT®
+ Chronic glaucoma induced by intracameral injection of magnetic microspheres
+ Chronic glaucoma induced by episcleral vein laser photocoagulation
+ Optic nerve injury induced by clamping
+ Spontaneous macular degeneration in NHPs
+ Choroidal Neovascularization (CNV) induced by laser photocoagulation
+ Retinopathy induced by lighting
+ CNV induced by stitching
+ CNV induced by NaOH burn
+ Allergic conjunctivitis induced by histamine instillation
+ Cataract induced by sodium selenite injection
+ Retinal ischemia reperfusion induced by elevating intraocular pressure
+ Retinitis pigmentosa monkey induced by sodium iodate injection
+ CNV induced by AAV-VEGF injection
+ Central vein occlusion induced by laser photocoagulation